PreadProfiler: Multilayer-omic Analysis of Adipose Tissue Progenitor Cell Heterogeneity
Adipose Progenitor Heterogeneity: A Tale of two Depots
Adipocyte precursor cells (APCs) reside, in part, in the adipose tissue vasculature as a subset of PDGFRb+ perivascular mesenchymal cells. Single-cell RNA-sequencing as revealed the functional and molecular heterogeneity of these cells in anatomically distinct WAT depots.
The PreadProfiler is a comprehensive and integrated dataset developed by the Wu Lab and Gupta Lab that provides the transcriptomic and proteomic profile of murine PDGFRb+ adipose tissue progenitors at three levels:
localization (intraabdominal and subcutaneous adipose depots)
Sex (male and female mice).
15,477 transcripts quantified by RNA-seq
4,870 proteins quantified by DIA Mass Spectrometry
4,540 genes represented at both the protein and mRNA level
Shan B, Barker, CS, Shao M, Zhang Q, Gupta RK, Wu Y. Under Review 2021
Multilayer-omics Reveal Sex- and Depot-Dependent Adipose Progenitor Cell Heterogeneity
